'This work will be built upon here and by other researchers worldwide to advance our approach to figuring out ways to target cancers'
Establishing cellular identity has been key to understanding the multitude of different cells in our body and their respective biological duties. Aissued by scientists from Trinity College Dublin leading a team details an important revelation that has the potential to impact cancer biology and targeted treatments.
Professor Adrian Bracken and his team based in Trinity's School of Genetics and Microbiology studied the workings of Polycombcomplexes PRC1 and PRC2. Ellen Tuck, a Ph.D. student, analogizes these proteins to “strict librarians” inside cells. “PRC1 and PRC2 block access to certain areas of the genetic library such that a neuron cell won’t have access to muscle genes, and it doesn’t get confused in its cellular identity,” she added.
The team, spearheaded by Dr. Glancy and Postdoctoral researcher Dr. Cheng Wang in collaboration with scientists in Italy and Netherlands, published their work in the leading journal Molecular Cell. Their findings are of great relevance to the field of chromatin and epigenetics research and can impactProfessor Bracken and his team worked through the COVID-19 pandemic shutdown keeping up with their tight deadlines and undeterred by failed hypotheses and failed experiments while maintaining social distancing measures to attain this significant breakthrough.
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