Researchers have delved into molecular 'de-extinction,' studying ancient genomes for potential antibiotics. Their work unearthed antimicrobial molecules from Neanderthals and Denisovans, challenging traditional notions of protein functions and raising bioethical queries. “We need to think big in
Marrying artificial intelligence with advanced experimental methods, the Machine Biology Group has mined the ancient past for future medical breakthroughs, bringing extinct molecules back to life. Credit: Ella Marushchenko
De la Fuente is Presidential Assistant Professor in the Department of Bioengineering and the Department of Chemical and Biomolecular Engineering at the. He holds additional primary appointments in Psychiatry and Microbiology in the Perelman School of Medicine. The team next applied these molecules to pathogens in a dish and in mice to test the veracity and efficacy of their computational predictions.
In fact, the group’s previous research had already shown that some of the antimicrobial molecules they found were hidden away, encrypted within proteins associated with completely different systems and functions in the body. “We are opening an entirely new avenue for learning about the ways our bodies prevent and fight diseases,” says de la Fuente.
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