Understanding how aspirin reduces inflammation could lead to alternatives with fewer side effects. New research has revealed important information about how aspirin works. Even though this drug has been available commercially since the late 1800s, scientists have not yet fully elucidated its deta
New research sheds light on the mechanism of action of aspirin, a widely used medication for pain, fever, inflammation, and reducing cardiovascular disease risk. Although aspirin’s inhibition of the cyclooxygenase enzyme is known, its detailed cellular targets have remained unclear. Findings from a study led by Subhrangsu Mandal, a professor at the University of Texas at Arlington, could help develop safer aspirin alternatives and potentially improve cancer immunotherapies.
Scientists know that aspirin inhibits the cyclooxygenase enzyme, or COX, which creates messenger molecules that are crucial in the inflammatory response. Researchers led by Subhrangsu Mandal, a professor of chemistry and biochemistry at the University of Texas at Arlington, have discovered more about this process.
Prarthana Guha, a graduate student in Mandal’s lab, presented the team’s findings at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, March 25–28 in Seattle. Avisankar Chini also made significant contributions to the study. The team found that aspirin controls transcription factors required for cytokine expression during inflammation while also influencing many other inflammatory proteins and noncoding RNAs that are critically linked to inflammation and immune response. Mandal said this work has required a unique interdisciplinary team with expertise in inflammation signaling biology and organic chemistry.
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