Safety data on combining immune checkpoint inhibitors and radiotherapy in breast cancer are limited because concurrent radiotherapy has typically been excluded in pivotal trials. This article explores the challenges and cautious approach in combining these treatments.
Safety data on combining immune checkpoint inhibitors and radiotherapy in breast cancer are limited because concurrent radiotherapy has typically been excluded in pivotal trials. If trials evaluating new targeted therapies included concurrent radiotherapy, it would be challenging to identify whether toxicities came from the drug itself, the radiation, or the combination.
Given the limited evidence, "we tend to be cautious and conservative" and not combine therapies that "we don't know are safe or appropriate for patients," said Chirag Shah, MD, director of breast radiology at the Cleveland Clinic, Cleveland, Ohio. Below is a guide to what we do and don't know about combining radiotherapy and systemic treatments in breast cancer
Radiotherapy Systemic Treatments Breast Cancer Immune Checkpoint Inhibitors Safety
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