Carbon-encapsulated magnetite nanodonut proposed for synergistic cancer therapy

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Carbon-encapsulated magnetite nanodonut proposed for synergistic cancer therapy
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Using the Steady-State High Magnetic Field Experimental Facility, researchers led by Prof. Wang Hui from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, in collaboration with researchers from the University of Washington, have constructed a photoresponsive carbon encapsulated magneto nanodonut (CEMNDs) nanoenzyme with dual catalytic activity for photothermally enhanced chemodynamic cancer synergistic therapy.

Iron-based nanoenzyme-mediated chemodynamic therapy has attracted much attention in recent years for catalytic tumor therapy. However, the limited uptake of iron-based nanoenzymes by tumor cells and the weak release of iron ions makeIt is effective to create the quasi-two-dimensional structure of the iron-based nanoenzyme to enhance tumor cell uptake.

In this study, the researchers introduced light-responsive CEMNDs that exhibited dual catalytic activities for CDT. "CEMNDs can accumulate within tumor sites and penetrate tumor cells, where they act as peroxidase enzymes to convert H

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