'Brain Aging' May Link Heart Disease, Dementia Risk

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'Brain Aging' May Link Heart Disease, Dementia Risk
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'Brain aging' may link heart disease, dementia risk MedTwitter

The study holds possible clues to the identity of that"something else." Accelerated brain aging in these patients with IHD was also correlated with diabetes, body-mass index , and especially waist-to-hip ratio, a surrogate for central adiposity. But there was no such significant correlation with BMI or waist-to-hip ratio among patients without IHD.

Such speculation is beyond the scope of the current study, observed Rauseo. But other research, she said, is exploring possible associations between inflammatory markers in IHD and later development of Alzheimer's disease or other forms of dementia. Of those, 1341 participants had IHD — defined as angina, myocardial infarction,"or any manifestation of IHD not resulting in infarction" — and 35,237 were without IHD.

Among the remaining IHD participants, the difference between brain chronological age and MRI-predicted brain age averaged 4.69 years. The mean difference among those with IHD was 6.96 years ,"indicating an older-appearing brain" compared with the non-IHD group.

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