A baby in North Carolina has received a first-of-its-kind heart transplant that may prevent his body from rejecting the organ without the need for lifelong drugs to suppress the immune system.
Because the thymus plays an important role in immune system function – in particular, teaching the body to recognize its own cells and tissues versus foreign invaders – it's possible that this combination transplant could allow the child's body to accept the new heart as part of itself instead of treating it as a foreign organ.
If the approach proves successful, it could potentially"be applied to all solid organs down the road," Turek said.Easton was born with a heart defect and underwent open heart surgery at just 5 days old, according to Duke University. Then, doctors discovered that Easton also had a thymus condition that meant he would need transplanted thymus tissue.
With special approval from the Food and Drug Administration, Easton's doctors performed his heart transplant on Aug. 6, 2021, when he was 6 months old; and two weeks later, they implanted thymus tissue from the same donor that had been cultured in a laboratory.
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Baby gets first-of-its kind heart transplant to help fight rejectionA 1-year-old boy who was born with a congenital heart defect and underwent three open-heart surgeries in his first months of life, now has a new heart. Easton Sinnamon, of Asheboro, North Carolina, underwent a first-of-its kind heart transplant. With the transplanted thymus tissue comes the hope that Easton will have to take much smaller doses of the immunosuppressive drugs transplant recipients typically have to take for the rest of their lives, according to Joseph W. Turek, M.D., Ph.D., chief of pediatric cardiac surgery at Duke University Hospital, and the doctor who oversaw Easton's transplants.
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