A drug that inhibits inflammation helped mice live longer and reduced the animals’ incidence of cancer and age-related health problems
Blocking an inflammatory molecule known as interleukin-11 extends the lifespan of mice, suggesting that drugs inhibiting IL-11 may haveantibodies
to block IL-11. The mice received an injection every three weeks starting at 75 weeks of age – comparable to about 55 years old in humans – until they died. A separate group of 38 mice received a different antibody therapy that didn’t target IL-11. The researchers found that blocking IL-11 extended the lifespan of both male and female mice by more than 20 per cent. In further experiments, animals treated with the anti-IL-11 therapy were less likely to develop cancer: less than 16 per cent of the treated rodents had tumours, compared with more than 60 per cent of those in the control group.The therapy also reduced cholesterol levels, frailty and body weight in the treated animals, and it improved their muscle strength and metabolism.
However, we won’t know if the same is true in people until clinical trials are conducted, says Cook. Multiple trials are under way to test anti-IL-11 therapies in people with certain inflammatory conditions, such as pulmonary fibrosis, but none is investigating its potential anti-ageing effects, he says.at Columbia University in New York. This makes it harder to know who may benefit from these types of anti-inflammatory therapies, she says.
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