Alzheimer’s, Parkinson’s, and Huntington’s all largely seem to stem from misfolded proteins—or, rather, our body’s inability to clear them out of our brains.
impact tens of millions of people worldwide every year. While there’s still a lot we don’t understand about diseases like Alzheimer’s, Parkinson’s, and Huntington’s, we do know that the issues largely seem to stem from misfolded proteins—or, rather, our body’s inability to clear them out of our brains.
“We’re very excited about these findings because we’ve not just found a new mechanism of how our microglia hasten neurodegeneration, we’ve also shown this can be interrupted, potentially even with an existing, safe treatment,” senior author David Rubinsztein, a dementia researcher at Cambridge, said in a statement.
However, they found that if they bred mice that had cells with inhibited CCR5 receptors, then they were protected against Huntington’s disease and proteins would build up less in these animal models. Coincidentally, CCR5 is also involved in how HIV targets our cells. That’s how the team turned to maraviroc, an HIV drug that inhibited the receptor, to fight neurodegenerative conditions in mice.
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