Science, Space and Technology News 2024
A new technique encapsulates ATP aptamer sensors in exosomes to cross the blood-brain barrier for brain imaging, aiding Alzheimer’s diagnosis and treatment. Tests in mice show sensors accumulate in the brain and highlight low ATP levels in affected areas. Credit: SciTechDaily.comThe method involves encapsulating ATP aptamer sensors in exosomes, which are able to cross the BBB and provide real-time imaging of neurotransmitter levels.
It is common for neurotransmitter levels to decrease with age, but low levels of the neurotransmitter adenosine triphosphate can be an indication of Alzheimer’s disease. To measure the location and amount of ATP in the brain, researchers have developed fluorescent sensors from pieces ofcalled aptamers that light up when they bind to a target molecule.
Researchers demonstrate exosomes loaded with fluorescent sensors that can pass through the blood-brain barrier where the sensors light up in the presence of neurotransmitters linked to Alzheimer’s disease in the brain. Credit: Adapted from ACS Central Science 2024, DOI: 10.1021/acscentsci.4c00563The BBB laboratory model consisted of a layer of endothelial cells on top of a solution containing brain cells.
Reference: “Delivering DNA Aptamers Across the Blood−Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models, 31 July 2024,, Welch Foundation, NIH Chemistry-Biology Interface Training Program at the University of Illinois Urbana-Champaign and a National Science Foundation Graduate Research Fellowship.SciTechDaily: Home of the best science and technology news since 1998. Keep up with the latest scitech news via email or social media.
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