Studying ~56 million T cells from 55 COVID patients, researchers in SciImmunology offer a high-res picture of epitope reactivity and TCR usage in CD8 T cells specific for SARSCoV2, some of which also react to “common cold” coronaviruses.
). This meager outcome was seen both for the cross-reactive “secondary responses” by memory T cells pre-primed by endemic HCoVs, as well as for the primary responses of truly SARS-CoV-2 species-specific CD8T cells amplified de novo.
This suggests that the paucity likely does not result from a blocking of primary activation, but from a dampening of all specific CD8Given the widespread lymphopenia observed in acute COVID-19, we considered the possibility of latent virus reactivation with the loss of protective CMV- and EBV-specific T memory pools. While we have no direct evidence of impact on disease outcome, we do observe a significant alteration of cell state within these subsets.
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