A shot of premade immune proteins, called a monoclonal antibody, could provide months-long protection against malaria.
The clinical trial tested different doses and delivered the medicine intravenously or as a shot. Based on a computer model of how the medicine is taken up, distributed and then cleared by the body, the researchers estimate that one shot may protect against malaria for six months.
has recently become available, but it is only modestly protective against the disease, and that protection wanes rapidly . The vaccine requires four shots. What’s appealing, she says, “is the possibility that you could give kids, even the youngest kids, an injection [of] premade antibodies that could last for six months or longer and protect them throughout the rainy season.” That once-a-season shot would be helpful in countries in West Africa, where malaria transmission only occurs during the rainy season.
Monoclonal antibodies are laboratory-made version of antibodies, the proteins that the immune system produces in response to a vaccine or natural infection. Monoclonal means that it contains clones, or copies, of one particular antibody.
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