A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

Indonesia Berita Berita

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
Indonesia Berita Terbaru,Indonesia Berita utama
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Researchers have designed an mRNA vaccine that delayed the onset of and reduced the severity of multiple sclerosis-like disease in mice. The vaccine restores the body’s tolerance to its own proteins, suppressing the disease's immune overreactivity.

5. J. Dalmau, F. Graus, Antibody-Mediated Encephalitis. N Engl J Med. 378, 840–851 .

6. J. Dalmau, C. Geis, F. Graus, Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 97, 839–887 . 7. J. Planagumà, F. Leypoldt, F. Mannara, J. Gutiérrez-Cuesta, E. Martín-García, E. Aguilar, M.J. Titulaer, M. Petit-Pedrol, A. Jain, R. Balice-Gordon, M. Lakadamyali, F. Graus, R. Maldonado, J. Dalmau, Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice. Brain. 138, 94–109 .

8. M. Malviya, S. Barman, K.S. Golombeck, J. Planagumà, F. Mannara, N. Strutz-Seebohm, C. Wrzos, F. Demir, C. Baksmeier, J. Steckel, K.K. Falk, C.C. Gross, S. Kovac, K. Bönte, A. Johnen, K.P. Wandinger, E. Martín-García, A.J. Becker, C.E. Elger, N. Klöcker, H. Wiendl, S.G. Meuth, H.P. Hartung, G. Seebohm, F. Leypoldt, R. Maldonado, C. Stadelmann, J. Dalmau, N. Melzer, N. Goebels, NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody.

Author contributions: FSI was responsible for conception and planning. All authors were responsible for analysis and interpretation of the data. FSI drafted the manuscript. All authors edited and approved the final manuscript.

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