An influenza vaccine is created by attenuating the live virus through targeted proteolysis NBTNV
Influenza has been overshadowed by the COVID-19 pandemic, but it remains a major threat to global health. Improved vaccines that deploy innovative technologies will be welcome additions to our options for the control of influenza. In a novel application of targeted degradation published in. describe the development of proteolysis-targeting chimeric influenza vaccines.
Despite their clinical efficacy and widespread uptake, influenza vaccines have well-known limitations. Influenza viruses undergo antigenic drift — a gradual accumulation of point mutations due to error-prone replication; mutations in the surface glycoproteins hemagglutinin and neuraminidase can generate variants that evade immunity induced by prior infection or vaccination.
Current seasonal influenza vaccines induce strain-specific immunity and generally lack efficacy against variants that have undergone antigenic drift or shift. Improved vaccines that can elicit broader and more durable immunity are a public health priority, and many next-generation influenza vaccines are in development.
PROTACs are bifunctional molecules that induce the degradation of a protein of interest by targeting it to the ubiquitin–proteasome system
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