Researchers have discovered a gene, Arrdc5, which could pave the way for a reversible, non-hormonal male contraceptive. The gene affects sperm count, movement, and shape, and a drug targeting the gene's protein would avoid hormonal interference, making it easily reversible. The Discovery of a gen
Researchers at Washington State University have discovered a gene called Arrdc5, expressed in the testicular tissue of mice, pigs, cattle, and humans, which could lead to the development of a highly effective, reversible, and non-hormonal male contraceptive for both humans and animals. The study found that when the gene was knocked out in mice, it caused infertility only in males by affecting sperm count, movement, and shape.
While other molecular targets have been identified for potential male contraceptive development, the Arrdc5 gene is specific to the male testes and found in multiple species. Importantly, lack of the gene also causes significant infertility creating a condition called oligoasthenoteratospermia or OAT.
Disrupting this protein wouldn’t require any hormonal interference, a key hurdle in male contraception since testosterone plays other roles beyond sperm production in men including building bone mass and muscle strength as well as red blood cell production. Designing a drug to target this protein would also make it easily reversible as a contraceptive.
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