The London man’s case, cautiously reported in the journal Nature as still too “premature” to be declared a cure, comes a decade after Timothy Brown, known in medical circles as the “Berlin patient,” was cured by a similar stem cell transplant.
Timothy Ray Brown, also known as the"Berlin patient," was the first person to be cured of HIV infection, more than a decade ago. Now researchers are reporting a second patient has lived 18 months after stopping HIV treatment without sign of the virus following a stem-cell transplant. By Carolyn Y. Johnson Carolyn Y.
Modern drug treatments for HIV have transformed an infection that was once a frightening death sentence into a disease that can be managed long-term, if people adhere to a lifelong medication regimen. Of the 37 million people infected worldwide, 21 million have access to therapy that can keep the disease in check.
— Donald J. Trump March 5, 2019 The London patient, infected with HIV and suffering from Hodgkin’s lymphoma, received bone marrow cells from a donor who had a malfunctioning CCR5 gene as part of his cancer treatment in 2016. The gene is known to create a protein that is crucial for HIV to invade white blood cells. Brown had also received a transplant without functioning CCR5 genes. In September of 2017, he stopped taking the drugs that had kept his virus in check for the last five years.
The new patient means that Brown, who decided in 2010 to reveal his identity and tell his story, is no longer alone.
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