Researchers have demonstrated the potential to heal injured lung tissue in chronic obstructive pulmonary disease (COPD) patients using their own lung cells for the first time. A study recently presented at the European Respiratory Society International Congress in Milan, Italy reported that 17 pa
Researchers have successfully used patients’ own P63+ lung progenitor cells to repair damaged lung tissue in COPD patients, improving their quality of life. Initial results from the phase I clinical trial were promising, showing improvement in lung function, breathlessness, and exercise capacity, with plans for a phase II trial underway.
To find new treatments for COPD, researchers have been investigating stem cells, which are capable of differentiating into any cell in the body, and progenitor cells, which are descendants of stem cells and can only differentiate into the cells that belong to the same tissue or organ and are normally used by the body to repair and replace damaged tissue. However, to date, the results have been conflicting, particularly for stem cells.
In this first phase I clinical trial, the researchers set out to investigate the efficacy and safety of taking P63+ progenitor cells from the lungs of 20 COPD patients, using them to grow millions more in the laboratory, before transplanting them back into the patients’ lungs. The cell treatment was well tolerated by all patients. After 12 weeks, the median diffusing capacity of the lungs , which tests how well air is exchanged between the lungs and the bloodstream, increased from 30% before treatment to 39.7% and then increased further to 40.3% at 24 weeks in the treated patients. The median distance covered in a six-minute walk distance test increased from 410 metres before treatment to 447 meters at 24 weeks.
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