In an animal model, the implantation of the valve restored the blood flow direction through the pulmonary artery without causing valve leakage.
A valve made of human collagen derived from cell cultures opens up new possibilities for treating pediatric heart diseases, according toResearchers from the BioTis laboratory have developed a pulmonary valve using human collagen. Such a device could revolutionize the treatment of pediatric heart diseases like tetralogy of Fallot, a congenital heart malformation characterized by pulmonary stenosis.
Both solutions have major drawbacks, however. First, an immune system rejection reaction can occur, which, along with chronic inflammatory reactions, may lead to other complications such as thrombosis and calcification. Second, valves made from these materials are prone to bacterial infections. Nor are they designed to accommodate the patient's growth and morphologic changes over time. This means that as the patient ages, further operations will be necessary to replace the initial valve.
The researchers tested the use of their biological leaflets to reconstruct a pulmonary valve in an"organosynthetic" heart model developed by their American collaborators at the Massachusetts Institute of Technology in Cambridge.
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