Ketamine pill depression treatment shows promise without psychedelic effects. Study highlights potential benefits for severe depre...
A new pill that slowly releases ketamine could treat people with severe depression without giving them the psychedelic side effects of the often-misused drug, early trial results suggested on Monday.
The drug has long been administered intravenously in clinics, but more recently a nasal spray using a derivative called esketamine has increased in popularity. The phase 2 trial involved more than 270 people with depression who had previously tried an average of four different anti-depressant drugs. "For patients who don't respond to conventional drugs, ketamine offers a way to avoid electro-shock therapy," he told AFP.
Last year,"Friends" actor Matthew Perry became the latest high-profile death from a ketamine overdose. But there is"the plausible concern that the widespread use of ketamine might trigger a new opioid style crisis," Oxford researcher Riccardo De Giorgi said in a 2022 BMJ editorial.
Psychedelic Effects Mental Health Study Ketamine Research Antidepressant Alternatives.
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