People who live past 100 are often mentally sharp despite having significant build-up of the amyloid plaques and tau tangles associated with Alzheimer's disease. Understanding their resilience could help us develop Alzheimer's treatments.
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For people who live to 100 or beyond, changes in the brain usually associated with Alzheimer’s disease don’t seem to correlate with cognitive impairment. For decades, researchers have suspected that clumps of proteins known as amyloid plaques and tau tangles were the main drivers ofYet a growing pile of evidence has also shown that many people who live into their …
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